There are no assurances about the content for people who buy so called 'legal highs'.
The warning from the Island's Drug Advice Service Helpline, or DASH,comes as Tynwald prepares to ban methoxetamine which is a synthetic version of Ketamine.
The white powder has not been tested for medical or industrial use so it could pose a significant risk to those taking it.
Shelley Stanley from DASH says unless a substance is professionally tested it's almost impossible to know what it's made up of:
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